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KMID : 0381319990380010011
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Korean Journal of Occupational Health
1999 Volume.38 No. 1 p.11 ~ p.22
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A Comparison of GC-NPD and GC-FID Methods for Analysis of N-Methylformamide in Urine from DMF Exposed Workers
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Abstract
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This purpose of the this study was to compare the results of two analytical techniques, GC-NPD and GC-FID, of quantifying urinary NMF from 70 DMF exposed workers in synthetic resins, leather, and dye manufacturing industries. In addition, the relationship between concentrations of airborne DMF and urinary NMF was investigated using samples Collected from 12 workers.
Airborne DMF was sampled using both charcoal and silicagel tubes. All urine specimens were collected both prior-to and at end-of workshifts.
The results were as follows:
1. The detection limits of urinary NMF by GC-FID and GC-NPD were 0.043mg/1 and 0.009, respectively. The recovery rates were 96.9% for the GC-NPD and 90.2% for the GC-FID methods.
2. Desorption efficiencies of DMF on Charcoal tubes were very poor with 32.96 %, while those on silicagel tubes were marginally acceptable with 85.70 %.
3. A statistically significant relationship between concentrations of airborne DMF and urinary NMF from 12 workers determined by GC-NPD (r=0.74) and by GC-FID (r=0.67) Was observed.
4. Geometric mean concentrations of urinary NMF of the end-of-shift urines from 70 workers were 15.84 mg/g creatinine by GC-NPD and were 9.88 mg/g creatinine by GC-FID, respectivery. For the prior-to-shift samples, they were 6.05 mg/g creatinine by GC-NPD and 92 mg/g creatinine by GC-FID.
These results of this study suggest that for collecting airborne DMF in the workplace, ilicagel tubes should be utilized. For quantifying urinary NMF concentrations as a biological arker of DMF exposed workers, urine should be collected at the end-of-shift. Urinary NMF should be analyzed by GC-NPD because of its lower limit of detection and better precision than that of GC-FID.
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